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Journal Publications

1.  J.C. Chen, K.K. Rhee, D.M. Beaudry and V.D. Ramirez (1984) In vivo output of dopamine and metabolites from the rat caudate nucleus as estimated with push-pull perfusion on-line with HPLC-EC in unrestrained, conscious rats.  Neuroendocrinology 38: 362-370.

2.  V.D. Ramirez, J.C. Chen, E. Nduka, W. Lin and A.D. Ramirez (1986) Push-pull perfusion (PPP) of the hypothalumus and the caudate nucleus (CN) in conscious, unrestrained animals. Annals of the New York Academy of Sciences 473:434-448.

3.  J.C. Chen and V.D. Ramirez (1988) In vivo dopaminergic activity from nucleus accumbens, substantia nigra and ventral tegmental area in the freely moving rat: basal neurochemical output and prolactin effect. Neuroendocrinology 48:329-335

4.  J.C. Chen and V.D. Ramirez (1988) Comparison of the effect of prolactin on dopamine release from the rat dorsal and ventral striatum and from the mediobasal hypothalamus superfused in vitro. European Journal of Pharmacology 149:1-8.

5.  J.C. Chen, P.B. Crino, P.W. Schnepper and L. Volicer (1989) Increased serotonin efflux by partially oxidized serotonin. Journal of Pharmacology and Experimental Therapeutics 250:141-148.

6.  J.C. Chen and V.D. Ramirez (1989) Effects of prolactin on tyrosine hydroxylase activity of central dopaminergic neurons of male rats: a NSD 1015 study. European Journal of Pharmacology 166:473-479.

7.  P.B. Crino, B.A. Vogt, J.C. Chen and L. Volicer (1989) Neurotoxic effects of partially oxidized serotonin: tryptamine-4,5-dione. Brain Research 504:247-257.

8.  P. Cai, J.K. Snyder, J.C. Chen and L. Volicer (1989) Preparation, reactivity and neurotoxicity of tryptamine-4,5-dione. Tetrahedron Letters, 31:969-972.

9.  J. Fishman, J. Rubins, J.C. Chen and L. Volicer (1991) Selective modification of guanine nucleotide-binding proteins by tryptamine-4,5-dione, a neurotoxic derivative of 5-hydroxytryptamine (serotonin). Journal of Neurochemistry 56:1851-1854.

10. J.C. Chen, J. Tonkiss, J.R. Galler and L. Volicer (1992) Prenatal protein malnutrition enhances serotonin release from hippocampus. Journal of Nutrition 122:2138-2143.

11. J.C. Chen, A. To, P.W. Schnepper and L. Volicer (1992) Neurochemical changes, tryptophan hydroxylase activity and serotonin uptake in rat brain after intraventricular administration of tryptamine-4,5-dione. Neuropharmacology 31:215-219.

12. J.C. Chen, E. Smith and J. Fishman (1992) The opioid receptor binding of dezocine, morphine, fentanyl, butorphanol and nalbuphine. Life Sciences, 52:389-396.

13. M.S. Moolten, J.B. Fishman, J.C. Chen and K.R. Carlson (1993) Etonitazene; an opioid selective for the mu receptor types. Life Sciences, 52:199-203.

14. G.J. Blatt, J.C. Chen, D.L. Rosene, L. Volicer and J.R. Galler (1994) Prenatal protein malnutrition effects on the serotonergic system in the hippocampal formation: an immunocytochemical, ligand binding, and neurochemical study. Brain Research Bulletin 34:507-518.

15. J.C. Chen, G. Turiak, J. Galler and L. Volicer (1995) Effect of prenatal malnutrition on release of monoamines from hippocampal slices. Life Sciences, 57:1467-1475.

16. J.C. Chen, J. Squepinilli, R. Fine and L. Volicer (1996) Neurotoxicity of free-radical mediated serotonin neurotoxin in cultured embryonic chick brain neurons. European Journal of Pharmacology, 303:109-114

17. J.C. Chen, G.Turiak, J.Galler and L.Volicer (1997) Postnatal changes of brain monoamine levels in prenatally malnorished and control rats. International Journal of Developmental Neurocsience 15: 257-263.

18. J.C. Chen, H.J. Su, L.I. Huang and M.C. Hsieh (1998) The Reductions of binding and functions of D2 dopamine receptors in the rat ventral striatum amphetamine sensitization. Life Sciences 64:343-354.

19. J.Y.Li, C.H.Wong, K.S.Huang, K.W.Liang, M.Y.Lin, P.C.Tan and J.C. Chen (1999) Morphine tolerance in arthritic rats and serotoninergic system. Life Sciences, 64:PL111-116.

20. J.C,Chen, J.-Y. Li, K.-W. Liang and Y.K. Huang (1999) Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the median prefrontal cortex. Brain Research 816:220-224.

21. C.L.Huang, H.C.Chen, N.K.Huang, D.M.Yang, L.S.Kao, J.C. Chen, H.L.Lai and YJ Cheren (1999) Modulation of dopamine transporter activity by nicotinic acetylcholine receptors and membrane depolarization in rat phechromocytoma PC12 cells. Journal of Neurochemistry 72:2437-2444.

22. P.C. Tan, J.C. Chen, J.Y.Li, K.W.Liang, C.H.Wong and Eagle Y.K.Huang (1999) Modulation of naloxone-precipitated morphine withdrawal syndromes in rats by neuropeptide FF analogues. Peptides, 20:1211-1217.

23. E.Y.-K. Huang, J.Y. Li, P.P.-C. Tan, C.H. Wong and J.C. Chen (2000) The cardiovascular effects of PFRPamide and PRF(Tic)amide, a possible agonist and antagonist of neuropeptide FF (NPFF). Peptides, 21:205-210.

24. J.C. Chen, K.W. Liang, C.S. Liang and Y.C. Chiang (2001) Significance of glutamate and dopamine neurons in the ventral pallidum during the expression of behavioral sensitization to amphetamine. Life Sciences, 68 (9): 973-983.

25. J.C. Chen, K.W. Liang and Eagle Y.K. Huang (2001) Differential effects of endomorphine-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects. Synapse, 39 (3): 239-248.

26. J.C. Chen, C.H. Wong, Y.K. Huang, T.C. Tang and J.Y. Li (2001) Modulations of spinal serotonin activity affect the development of morphine tolerance. Anesthesia and Analgesia 92(6):1563-1568.

27. Y.K. Huang, J.Y. Li, C.H. Wong, P.C. Tan and J.C. Chen (2002) Dansyl- PQRamide, a neuropeptide FF receptor analog, induces conditioned place preference. Peptides, 23 (3):489-496.

28. G.C. Yeh, J.C. Chen, H.C. Tsai, H.H. Wu, C.Y. Lin, P.C. Hsu and Y.C. Peng (2002) Amphetamine inhibits the N-methyl-D-aspartate receptor-mediated responses by directly interacting with the receptor/channel complex. Journal of Pharmacology and Experimental Therapeutics 300(3):1008-1016.

29. J.J. Hwang, M.H. Liao, T.C. Yen, S.P. Wey, K.J. Lin, W.H.T. Pan, J.C. Chen and G. Ting (2002) Biodistribution study of [99mTc]TRODAT-1 alone or combined with other dopaminergic drugs in mice with macroautoradiography. Applied Radiation and Isotopes, 57:35-42.

30. H.C. Hsieh, H.Y. Li, M.Y. Lin, Y.F. Chiou, S.Y. Lin, C.H. Wong and J.C. Chen (2002) Spatial and temporal profile of haloperidol-induced immediate early gene expression and phosphoCREB binding in the dorsal and ventral striatum of amphetamine- sensitized rats. Synapse, 45:230-244.

31. J.C. Chen, P.C. Chen and Y.C. Chiang (2003) D3 dopamine receptors are down-regulated in amphetamine-sensitized rats and their putative antagonists modulate the locomotor sensitization to amphetamine. Brain Research, 972(1-2):159-167.

32. Eagle Y.K. Huang, P.L. Tao, J.Y. Li, C.H. Wong and J.C. Chen (2003) Endomorphin-1 and -2 induce naloxone-precipitated withdrawal syndromes in rats. Peptides, 24:477-481.

33. K.J. Lin, T.C. Yen, S.P. Wey, J.J. Hwang, X.X. Ye, K.Y. Tzen, Y.K. Fu and J.C. Chen (2004) Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography. Journal of Nuclear Medicine, 45:673-681.

34. P.C. Chen and J.C. Chen (2005) Enhanced Cdk5 activity and p35 translocation in the ventral striatum of acute and chronic methamphetamine-treated rats. Neuropsychopharmacology, 30:538-549.

35. J.-S. Wang, Y.S. Li, J.C. Chen, and Y.W. Chen (2005) Effects of exercise training and deconditioning on platelet aggregation induced by alternating shear stress in men. Arteriosclerosis, Thrombosis and Vascular Biology, 25:454-460.

36. T.-H. Yeh, H.M. Hwang, J.C. Chen, Tony Wu, A.H. Li and H.L. Wang (2005) Glutamate transporter function of rat hippocampal astrocytes is impaired following the global ischemia. Neurobiology of Disease, 18:476-483.

37. J.C. Chen, H.C. Hong, J.L. Lu, Y.C. Chiang, H.M. Huang, H.L. Wang, Tony Wu, J.J. Liao and T.S. Yeh (2005) Down-regulation of the glial glutamate transporter GLT-1 in rat hippocampus and striatum and its modulation by a group III metabotropic glutamate receptor antagonist following transient global forebrain ischemia. Neuropharmacology, 49:703-714.

38. Eagle Y.K. Huang, W.Z. Li and J.C.Chen (2006) Rat NPFF1 receptor-mediated signaling: functional comparison of neuropeptide FF (NPFF), FMRFamide and PFR(Tic)amide. Peptides, 27:1005-1014.

39. P.C. Chen, C.L. Lao and J.C. Chen (2007) Dual alteration of limbic dopamine D1 receptor-mediated signaling and Akt/GSK3 pathway in dopamine D3 receptor mutants during the development of methamphetamine sensitization. Journal of Neurochemistry 100:225-241.

40. C.H. Huang, J.C. Cheny, J.C. Chen* and C.P. Tseng* (2007) Evaluation of the role of Disabled-2 in nerve growth factor-mediated neurite outgrowth and cellular signaling, Cellular Signaling, 19:1339-1347. (*corresponding)

41. Y.C. Chiang and J.C. Chen (2007) The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats, Journal of Neurochemistry, 103:2505-2517.

42. P.Y. Chang, C.H. Chuang, J.C. Chen and C.-S. Tung (2008) Behavioral and pharmacological effects of amperozide and serotonin agents on nigrostriatal and mesolimbic dopamine systems, J. Chinese Physiology, 51(2):106-115.

43. H.L. Liu, Y.Y. Wai, W.S. Chen, J.C. Chen, P.H. Hsu, X.Y. Wu, W.C. Huang, T.C. Yen and J.J. Wang (2008) Hemorrhage detection during focused-ultrasound induced blood–brain-barrier opening by using susceptibility-weighted magnetic resonance imaging, Ultrasound in Medicine & Biology, 34(4):598-606.

44. H-L Liu, P-H Hsu, P-C Chu, Y-Y Wai, J.C. Chen, C-R Shen, T-C Yen and J-J Wang (2009) Magnetic resonance imaging enhanced by superparamagnetic iron oxide particles: usefulness for distinguishing between focused ultrasound-induced blood-brain barrier disruption and brain hemorrhage. Journal of Magnetic Resonance Imaging 29:31-38.

45. J.C. Chen, P.C. Chen and Y.C. Chiang (2009) Molecular mechanism of psychostimulant addiction. Chang-Gung Medical Journal, 32:148-154.

46. P.C. Chen, C.L. Lao and J.C. Chen (2009) The D3 dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK-1 and Cdk-5, Journal of Neurochemistry, 110:1180-1190.

47. K.J. Lin, H.L. Liu, P.H. Hsu, Y.H. Chung, W.C. Huang, J.C. Chen, S.P. Wey, T.C. Yen and I.T. Hsiao (2009) Quantitative microSPECT/CT for detecting focused ultrasound induced blood-brain barrier opening in the rat, Nuclear Medicine and Biology, 36:853-861.

48. H-L Liu, Y-Y Wai, P-H Hsu, L-A Lyu, J-S Wu, C-R Shen, J-C Chen, T-C Yen and J-J Wang (2010) In vivo assessment of macrophage CNS infiltration during disruption of the blood–brain barrier with bocused ultrasound: a magnetic resonance imaging study, Journal of Cerebral Blood Flow & Metabolism, 30:177-186.

49. C.H. Hsieh, H.Y. Li and J.C. Chen (2010) Nitric oxide and interleukin-1b mediate noradrenergic induced corticotrophin-releasing hormone release in organotypic cultures of rat paraventricular nucleus, Neuroscience, 165:1191-1202.

50. F. Kersanté, J.-Y. Wang, J.-C. Chen, C. Mollereau and Jean-Marie Zajac (2011) Anti-opioid effects of neuropeptide FF receptors in the ventral tegmental area, Neuroscience Letters, 488: 305-309.

51. Y.-L. Shen, J.-C. Chen and R.-M. Liao (2011) Place conditioning and neurochemical responses elicited by the aftereffect of acute stressor exposure to an elevated stand, Neuroscience Letters, 504:156-159.

52. Y.T. Lin and J.C. Chen (2011) The involvement of dorsal root ganglia BDNF-TrkB in inflammatory pain in vivo and in vitro, Journal of Neuroinflammation, 8:126-147.

53. D.-J. Kao, Allen H Li, J.C. Chen, R.S. Luo, Y.L. Chen, J.C. Lu and H.L. Wang (2012) CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons, Journal of Neuroinflammation, 9:189.

54. P.K. Chao, K.T. Lu, Y.L. Lee, J.C. Chen, H.L. Wang, Y.L. Yang, M.Y. Cheng, M.F. Liao, L.S. Ro (2012) Early systemic granulocyte-colony stimulating factor treatment attenuates neuropathic pain after peripheral nerve injury, PLoS ONE, 8:1-13.

55. H.T. Chen, N.Y. Ruan, J.C. Chen* and Z.Y. Lin* (2012), Dopamine D2 receptor-mediated Akt/GSK3b signaling: Initiation by D2S receptor and role in quinpirole-induced behavioral activation, ASN NEURO, 4(6). (*, co-coresponding)

56. C.C. Lin, H.L. Hsieh, R.H. Shih, P.L. Chi, S.E. Cheng, J.C. Chen* and C.M. Yang* (2012) NADPH oxidase 2-derived reactive oxygen species signal contributes to bradykinin- induced matrix metalloproteinase-9 expression and cell migration in brain astrocytes, Cell Communication and Signaling, 10:35. (*, co-coresponding)

57. L.H. Chow, P.L. Tao, J.C. Chen, R.M. Liao, E.P. Chang and E.Y.K. Huang (2013) A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats. Peptides, 39:21-28.

58. T.C. Wu, H.T. Chen, H.Y. Chang, C.Y. Yang, M.C. Hsiao, M.-L. Cheng and J.-C. Chen (2013) Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior, Psychoneuroendocrinology, 38:871-883.

59. C.L. Lao, C.S. Lu and J.C. Chen (2013) Dopamine D3 Receptor activation promotes neural stem/progenitor cell proliferation through AKT and ERK1/2 pathways and expands type-B and -C cells in adult subventricular zone, Glia, 61:475–489.

60. P-H Hsu, K-C Wei, C-Y Huang, C-J Wen, T-C Yen, C-L Liu, Y-T Lin, J-C Chen, C-R Shen*, and H-L Liu* (2013) Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound, PLoS ONE, 8(2): e57682.

61. C.L. Lao, Y.H. Kuo, Y.T. Hsieh and J.C.Chen (2013), Intranasal and subcutaneous administration of dopamine D3 receptor agonists functionally restores nigrostriatal dopamine in MPTP-treated mice, Neurotoxicity Research, 24:523-531.

62. Y.C. Chiang, Y.N. Lo and J.C. Chen (2013) Crosstalk between Dopamine D2 receptors and cannabinoid CB1 receptors regulates Cnr1 promoter activity via ERK1/2 signaling, Journal of Neurochemistry, 127:163-176.

63. H.T. Chen and J.C. Chen (2014) Role of the ventral tegmental area in methamphetamine extinction: AMPA receptor-mediated neuroplasticity, Learning and Memory, 22:149-158.

64. Y.T. Lin, S.C. Kao, Y.J. Day, C.C Chang and J.C. Chen (2015) Altered nociception and morphine tolerance in neuropeptide FF receptor type 2 over-expressing mice, European Journal of Pain, 20:895-906.

65. Y.T. Lin, T.Y. Liu, C.Y. Yang, Y.L. Yu, T.C. Chen, Y.J. Day, C.C. Chang, G.J. Huang and J.C. Chen (2016) Chronic activation of NPFFR2 stimulates the stress-related depressivebehaviors through HPA axis modulation, Psychoneuroendocrinology, 71:73-85.

66. W.Y. Tzeng, H.H. Wu, C.Y. Wang, J.C. Chen, L. Yu and C.F. Cherng (2017) Sex differences in stress and group housing effects on the number of newly proliferated cells and neuroblasts in middle-aged dentate gyrus. Frontiers in Behavioral Neuroscience, 10, 249.

67. Y-T Lin, H-L Liu, Y-J Day, C-C Chang, P-H Hsu and J.C. Chen (2017) Activation of NPFFR2 leads to hyperalgesia through the spinal inflammatory mediator CGRP in mice, Experimental Neurology, 291:62-73.


68. Q-C Moa and J.C. Chen (2017) Reduced neuregulin 1 expression in the medial prefrontal cortex of rat ketamine model for schizophrenia, Neuropsychiatry, 7(3):640-647.


69. S.F.H. Waqas, A. C. Hoang, Y.T. Lin, G. Ampem, H. Azegrouz, L. Balogh,  J.Thuróczy, J.C. Chen,  I. C. Gerling, S. Nam, J.S. Lim,J. M. Ibañez, J. T. Real, S. Paschke,R. Quillet,S. Ayachi, F. Simonin,E. M. Schneider,J. A. Brinkman,D.W. Lamming,C.M. Seroogy,and T. Röszer (2017) Neuropeptide-FF increases M2 activation and self-renewal of adipose tissue macrophages.The Journal of Clinical Investigation, JCI90152.

70. S.Y. Chang, T.S. Hsieh, W.R. Chen, J.C. Chen and C Chou (2017) Measurement of tissue- radiation dosage using a thermal steady-state elastic shear wave, Journal of Biomedical Optics, 22(8), 085001.

71. Y.T. Lin, Y.L. Yu, W.C. Hong, T.S. Yeh, T.C. Chen and J.C. Chen (2017) NPFFR2 activates the HPA axis and induces anxiogenic effects in rodents, International Journal of Molecular Sciences, 18, 1810.


72.Y.T. Lin and J.C. Chen (2018) Dorsal root ganglia isolation and primary culture to study neurotransmitter release, JOVE, in press.

73. P-K Chang, L. Yu and J.C. Chen (2018) Dopamine D3 receptor blockade rescues hyper-dopamine activity-induced deficit in novel object recognition memory, Neuropharmacology, 133:216-223.

74. S.H. Huang, W.R. Wu, L.M. Lee, P.R. Huang and J.C.Chen (2018) mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine, Progress in Neuropsychopharmacology & Biological Psychiatry, 86:331-339.

Books & Chapters
  1. J.C. Chen, A. Ramirez and V.D. Ramirez (1985) Prolactin effect on in vivo striatal dopaminergic activity as estimated with push-pull perfusion in male rat. In: Prolactin, Basic and Clinical Correlates, R.M. Macleod et al., eds., Liviana press, pp.523-532.

  2. L. Volicer, J.C. Chen, P.B. Crino, B.A. Vogt, J. Fishman, J. Rubins, P.W. Schnepper and N. Wolfe (1989) Neurotoxic properties of a serotonin oxidation product: possible role in Alzheimer's disease. In: Progress in Clinical and Biological Research Vol. 317: Alzheimer's Disease and Related Disorders, Alan R. Liss, Inc., NY, pp. 453-465.

  3. 藥理學  1999年 楊春茂 林麗慧 陳景宗 余淑美 林光輝 郭詩憲合著 匯華圖書出版有限公司 (ISBN 957-594-026-1 C5430)

  4. 掌握優勢的關鍵 腦科學知識  2004年 曾志朗 洪蘭 賴其萬 胡海國 白明奇 朱迺欣 謝仁俊 陳景宗合著 東元科技文教基金會 (ISBN:9789570829020)

  5. 物質濫用 Chapter 5.中樞神經興奮劑  2014年 陳景宗 江耀璋 衛生福利部食品藥物管理署 (ISBN 978-986-04-3813-0)

  6. 彩色圖解藥理學 (Pharmacology: An Illustrated Review) 2017年 陳景宗 黃翊恭 江耀璋 林雅婷 黃信翰 合譯 合記出版社

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